microcrystalline cellulose msds fmc microcrystalline cellulose msds fmc

Revision No. 2021 Annual Report. EINECS #: 232-674-9 1.7. No. Eur., JP Product Specifications: Chemical and Physical: Loss on drying 2.0 - 5.0 %* Bulk density 0.29 - 0.36 g/cc Identification A, B Passes Degree of polymerization NMT 350 units pH 5.5 - 7.0* Conductivity NMT 75 S/cm By producing Avicel . MATERIAL SAFETY DATA SHEET Avicel PH Microcrystalline Cellulose MSDS Ref. >> stream Microcrystalline cellulose -The oldest polymer finds new industrial uses,. Our customers around the world enjoy the benefits of TEXTURECEL NaCMC in various wound care products, too. Watch Now. Manufactured by: China . Find answers in our support articles. Avicel Microcrystalline Cellulose: A Guide to Grades and Uses, Working Hours (Mon to Friday): 08:30 - 17:30, legendary Canadian-born chemist, Orlando Aloysius Battista, United States Pharmacopoeia and National Formulary, United States Food and Drug Administration, Quantitative nutritional analysis of Avicel Microcrystalline cellulose (in 100g), https://doi.org/10.1016/0378-5173(95)04231-8, https://doi.org/10.1016/j.ejpb.2004.05.009, https://doi.org/10.1002/9783527682935.ch04, Pharmaceutical Acronyms and Abbreviations, Glossary of Terms Used in the Pharmaceutical Industry, Standard Terms & Conditions Of Sale Of Goods And Services, 4-O-[(1S)-hexopyranosyl]-D-glycero-hexopyranose. 102331. %PDF-1.3 Microcrystalline Cellulose / Avicel PH-102. Avicel co-processed products are high functionality excipients offering improved powder flow, granule properties, tablet compression, and mouth feel. common form is used in vitamin supplements or tablets. CAS #: 9004-34-6 1.6. The typical mean particle size is 20200 m. GRINDSTED Xanthan Gum readily dissolves in water under ambient conditions without the need of special high-shear equipment. MATERIAL SAFETY DATA SHEET Avicel PC 611 Microcrystalline Cellulose Page 1 of 8 MSDS Ref. If breathing is difficult or if . Battista, O. These co-processed products are designed to solve complex formulation problems, simplify manufacturing processes, and deliver significant cost savings. The product range encompasses methylcellulose and hydroxypropyl methylcellulose (hypromellose) each available in different grades to address a wide range of applications including tablet coatings, granulation, controlled release, drug layering, vegetarian hard-shell capsules and amorphous drug stabilization. q9;v80q>jZ <> Avicel CL-611 Microcrystalline Cellulose and Sodium Carboxymethylcellulose Page 1 of 9. iq/iVO"5VI}dn.#q^(fJ),BN yb5*4reh1"!E?mR*%fK,e4?A\{OAXr1' tx&Ul{J,57n%PV E2eMS5'UOL wdD{s)4N-m ab K * ~CVHg}{J2.M}O)^}|Z{V+ >AW|? eqgP}OF'v7heLP&Y,eoo`x7lR}0iRVP],=`_2rS'*X$b)+XV2;fbQDgkgx:IZ|v>lDD/TDqz %RL vdZ@Rgl{eU+7N!3!|hUmW)~}U*7k i@j)q["MEydtP"ftFu]t }JN~A"8lz7#}J.i@ qaj/QU<5OrVMfl{pL? PROSOLV SMCC, silicified microcrystalline cellulose, is a unique combination of microcrystalline cellulose (MCC) and colloidal silicon dioxide (CSD).A high functionality and multifunctional excipient, it requires less complex processing, has high inherent functionality, and passes that functionality on to the drug formulation. <> Alubra sodium stearyl fumarate from IFF Pharma Solutions is a comparatively hydrophilic lubricant widely used in capsule and tablet formulations. It is generally regarded as a relatively nontoxic and non-irritant material that is safe for human and animal consumption. Synonyms: Cellulose, Cellulose powder, Cotton linters. << !,K`I[O@U|$+i 8sB|+"B@'2^7[2XKrd#5b With an account you can check out faster, view your online order history and access your shopping bag or saved items from any device. The smallest units, the elementary fibrils (cellulose crystalline strands) are made up of many -(1-4) glucose chains which are bundled to form microfibrils. AFFINISOL hydroxypropyl methylcellulose (HPMC) is a water-soluble cellulosic polymer that can help optimize solubility enhancement of poorly soluble drugs by maintaining stable solid dispersions and inhibiting API crystallization. >> MATERIAL SAFETY DATA SHEET Version: 1.0 1. bEI3%UxI"M_1)5b/c;/\~3:?/9S\\9/%I3nn2foO^MgX0n: O FMC has deep roots in the food production system worldwide learn more about our latest advances in the future of agriculture. % (1962). : 5. Microcrystalline cellulose is a commonly used excipient in the . Molecular weight: Not Applicable 1.5. Product Specifications: Chemical and Physical: Loss on drying, % NMT 6.0* Viscosity, cps, 1.2% solids, 120 sec 39 to 91 . Pharmacel 112 can be used in a wide range of oral solid dosage (OSD) forms as binder, compressing agent . Regulatory Information Standard, 29 CFR 1910.1200 and Canada's Workplace Hazardous Materials Information System (WHMIS . Avicel Microcrystalline cellulose is manufactured in the United States of America by Dupont. Are you sure you want to delete your template? B;vLZpHU%ChUyD+[ Learn about our new global sustainability platform, Learn about FMC's industry leading goal of net-zero emissions by 2035, Learn about FMC's differentiated biologically-based crop solutions. Dupont acquired the microcrystalline cellulose business of FMC Corporation in 2017. TEXTURECEL NaCMC is applied in oral solids, such as granules and pellets, powders as well as coatings for tablets. Your file is uploaded and ready to be published. Alginates also function as actives in some anti-reflux products. P}MFbN#[>r(y Material Safety Data Sheet or SDS for Microcrystalline cellulose 9004-34-6 from chemicalbook for download or viewing in the browser. They are white to off-white, free-flowing hydrophilic powders supplied in a variety of viscosity grades corresponding to approximate molecular weight, ranging from 100,000 to 7,000,000 daltons. We can send by Fedex, by ship or by plane according to international rules. Material Safety Data Sheet Ethyl Alcohol 70 ACC 91791 April 21st, 2019 - Material Safety Data Sheet Ethyl Alcohol 70 ACC 91791 Section 1 Chemical Product and Company Identification Ethanol has been shown to produce fetotoxicity in the embry o or fetus of laboratory animals Prenatal Chemical waste generators must determine The main source of cellulose is woody plants, since it is the main building block of the cell walls of higher plants. 6 0 obj Product Name Cellulose microcrystalline. Since cellulose contains both amorphous and crystalline regions, when the crystalline regions are mechanically and chemically isolated and elaborated, various useful ingredients in the form of cellulose crystals are obtained, one of which is Avicel Microcrystalline cellulose. Medium size standard MCC grade, suited for the majority of directly compressible actives. : CL-611NF Date Approved: 01/13/2010. EMCOCEL 90 M. 130. Chemsrc provides Cellulose microcrystalline(CAS#:9004-34-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Avicel Microcrystalline Cellulose: Chemical Identifiers. Quick Links. FMC Corporation 2929 Walnut Street Philadelphia, PA 19104 (215) 299-6000 (General Information) . 0.25 - 0.37. LATTICE Microcrystalline Cellulose has many important uses within the food, pharma, specialty applications and industrial such as non-stick coatings, insulation of wiring, crop protection and paints,coats and inks. Material safety data sheet (MSDS) of the m icrocrystalline cellu lose (MCC) gwf;J(e0o|1p{R~P^);ao!%{0KD7. endobj It is made from purified partially depolymerised Alfa cellulose relatively free from both organic and inorganic contaminants. At the same time, its pronounced shear-thinning behavior enables handling of even highly viscous solutions. Learn about FMC's industry leading goal of net-zero emissions by 2035. METHOCEL products have been in continuous production for more than 70 years with production facilities and deep product expertise located around the globe. Aquacoat sustained release coating is a pseudo latex aqueous dispersion of water insoluble polymers used for sustained and enteric coating applications. CAS #: 9004-34-6 . FMC, JRS and Mingtai were estimated to hold for . CAS #: 9004-34-6 In extrusion-spheronisation, it is the excipient of choice. }o]X4]. This unique functionality can be used in a diversity of applications such as controlled release dosage forms, enteric coatings, microencapsulation and stabilization in solutions and suspensions. {iy7uEijn0y]"s"gbV~p8Q)zN:cyvs]&,kk=6pcA %iBW|2nKa)Jb7` 0 endstream endobj 524 0 obj 458 endobj 525 0 obj << /Filter /FlateDecode /Length 524 0 R >> stream Production of Pharmaceutical Grade Microcrystalline Cellulose. : 160182 Date Approved: 05/25/2010 Revision No. The most. Ui[(lY[|//o)ZmqbQT-Y.M|se[)m?(WRV.W8J/j}9>X.VNsZNOp'^14nuXM%rea5]@ MKnNe %PDF-1.4 Patel, F. Podczeck, Investigation of the effect of type and source of Microcrystalline Cellulose on capsule filling, International Journal of Pharmaceutics, 128 (1996) 123-127. In Cellulose and Cellulose Derivatives in the Food Industry, T. Wstenberg (Ed. J]3yzZ2Z$mZ7o%-Xyq'()V9KX0gk~AA Cu:3(]N"AQdUt~h|P X]s ;/4'OslUK:|QY`IL|w @ I!*2T~IN?*}y2*49]yOQ*VG%Gu,;&9zE{q==xvrv}rd(yG*qN6E0K$IBWhe In large quantities it provides dietary bulk and may lead to a laxative effect. JRS Pharma: PROSOLV SMCC 90: Microcrystalline Cellulose, Colloidal Silicon Dioxide: 125: 0.25 - 0.37: Formulas in which a balance of flow and compaction is required. Similarly, the European Food Safety Agency has also evaluated Microcrystalline cellulose and established that it is not absorbed systemically and excreted unchanged. CAS 9004-34-6, pH 5 - 7.5. JRS Pharma: PROSOLV SMCC 90 LM: Microcrystalline Cellulose, Colloidal Silicon . Its used in capsules and tablets, both in wet granulation and direct compression processes, where it serves as a moisture adsorbent, tablet, and capsule diluent, and tablet disintegrant.It is also widely used as a supplementary formulation aid, primarily to enhance the . The chemical structure of cellulose is shown below: In the biosynthesis of cellulose, two molecules of -D-glucose molecules combine via a condensation reaction (elimination of one molecule of water) to form the so-called cellobiose unit. pH 6.0 to 8.0 . Cellulose is a linear polymer of -D-glucose, linked through carbon atoms 1 and 4. No. Molecular Weight null. 10.1 Future Forecast of the Global Microcrystalline Cellulose Market from 2023-2028 Segment by Region 10.2 Global Microcrystalline Cellulose Production and Growth Rate Forecast by Type (2023-2028 . Protect them from sunshine or rain. endobj Interestingly, the discovery of Avicel was accidental, the team was attempting to break up hydrolysed cellulose . Microcrystalline Cellulose (MCC) Manufacturing Industry. Within the pharmaceuticals field, where the bulk of this material is utilised, Avicel Microcrystalline cellulose functions as a filler and diluent, dry binder, flow, disintegrating, and compression aid in tablets, capsules, and granules. We are artists at heart and creators by nature. In 1964 FMC, Corporation . Product name: Microcrystalline cellulose; CBnumber: CB4217972; CAS: 9004-34-6; EINECS Number: 232-674-9; Synonyms: MICROCRYSTALLINE CELLULOSE,cellulose; Avicel PH-200 microcrystalline cellulose NF, Ph. The data shown below apply only to Avicel PH 101. MATERIAL SAFETY DATA SHEET Avicel RC/CL Microcrystalline Cellulose and Sodium Carboxymethylcellulose MSDS Ref. Unique functionality for a broad range of pharmaceutical applications. Material Safety Data Sheet or SDS for Cellulose microcrystalline 102331 from Merck for download or viewing in the browser. %PDF-1.4 q9;v80 >z+{!A6wy @nLK3R#hRn sba3;b61V:#Z3X,*?RC!wPmqd7WkA'aZMt6PFV3SEvlY'=p.mn[I{puc\6'ZIyI%rD'zA!"t3I2F ^R;LK,?:&THv*y^K> o0Af?J9J-{s2&cCn)32ADzl%sS5O~J[ Description: Microcrystalline Cellulose E460 is a term for refined wood pulp manufactured through plant fibre hydrolysis. Currently, it is marketed both directly and indirectly (through distributors) depending on the country in question. Some substance identifiers may have been claimed confidential, or may . 4 0 obj Have an order or account question, find answers in our Online Support articles. The highly reactive amorphous regions selectively hydrolyze, releasing the crystallites, which are subsequently mechanically dispersed. stream From anti-reflux to biomedical implants, alginates are uniquely suited for a wide range of applications. Test Data Available. G2W4de=u183KGH{ vQ#4:1\wc 1 0 obj FMC Corporation: Co-processed microcrystalline cellulose and sugar alcohol as an excipient for tablet formulations DE102009022738A1 (de) * 2009-05-26: 2010-12-09: J. Rettenmaier & Shne Gmbh + Co. Kg . Non-woody sources are also viable sources of cellulose, although only woody plants and cotton are the main sources for microcrystalline cellulose used as a pharmaceutical excipient. Learn about FMC's differentiated biologically-based crop solutions. Avicel Microcrystalline cellulose was discovered in 1955 by a team at FMC Corporation, led by the legendary Canadian-born chemist, Orlando Aloysius Battista, which he initially named mechanically disintegrated D.P cellulose. Doses up to 30 g per day appear to be . 2008-2023 ChemPoint. This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication The table below lists the most important chemical identifiers applicable to Avicel Microcrystalline cellulose. To overcome the pitfalls of known overlays, we tested suspensions of microcrystalline cellulose Avicel RC/CLtrade mark as overlay media in the plaque and plaque-inhibition assay of influenza viruses. The charts below provide guidance on how to select and use standard and co-processed grades of Avicel Microcrystalline cellulose in pharmaceutical products. Microcrystalline cellulose (Avicel, FMC Corporation) is prepared by acid hydrolysis of cellulose using 2 M hydrochloric acid at 105 C for 15 min. <> Packaging: 34 x 50 kgs fiber drums. Magazine: Material safety data sheet - FMC Corporation. More sophisticated drug discovery techniques have led to pipeline compounds that require solubility enhancement to be therapeutically effective. We are the leading manufacturer of Microcrystalline Cellulose coated with - RC 581 Grade in the industry. SUBSTANCE IDENTIFICATION 1.1. Heavy metals, % NMT 0.001 Product Name: Microcrystalline Cellulose E460 1.2. The global microcrystalline cellulose (MCC) market was valued at $401.1 million in 2021, and is projected to reach $712.9 million by 2031, growing at a CAGR of 5.9% from 2022 to 2031. Chemical Formula: (C6H10O5)n 1.4. Microcrystalline Cellulose E460 MSDS 1. Page 1 of 8. X\o^ HAZARDS IDENTIFICATION EMERGENCY TELEPHONE NUMBERS (302) 451-0100 (FMC Plant - Newark, Delaware) (303) 595-9048 (Medical - U.S. - Call Collect) For leak, fire, spill, or accident emergencies, call: (800) 424-9300 (CHEMTREC - U.S.A. & Canada) (703) 527-3887 (CHEMTREC - Collect - All Other Countries) EMERGENCY OVERVIEW: Off-white, free-flowing, odorless powder. Various Gelcarin and Viscarin carrageenan grades are used by the pharmaceutical industry to achieve specific gelling for controlled drug release, thickening, and stabilizing properties desired in various formulations. Aqueous suspensions of microcrystalline cellulose have . <> To help, weve put together a simple guide for selecting Avicel Microcrystalline cellulose grades, with simple explanations of some of the most common grades, plus recommendations that will serve the majority of buyers. The product would later go on to be commercialized under the brand name Avicel by FMC Corporation. As one of the most robust and efficient excipients, it tolerates high salt content, high temperature and is stable in a wide pH range. microcrystalline cellulose and carboxymethylcellulose sodium NF, Ph. Cellulose microcrystalline Revision Date 25-Dec-2021 SARA 313 Not applicable SARA 311/312 Hazard CategoriesSee section 2 for more information CWA (Clean Water Act) Not applicable Clean Air Act Not applicable OSHA - Occupational Safety and Health Administration Not applicable CERCLA Not applicable California Proposition 65 This product contains the following Proposition 65 chemicals. It is available in different grades and particle sizes. Apply today! : 9004-34-6 1.2 Relevant identified uses of the substance or mixture and uses advised against Aquacoat CPD is an aqueous dispersion of cellulose acetate phthalate used for enteric release applications. XiDqLN MD'F2`jI7ZWu,JK%5e9~:R>LAm\WyY0lk=ZNP;pZ23)P0GG~%e[ d8GIXRo&. Explore how we work and why we apply science and creativity for a better world to everything we do. Product Name: MICROCRYSTALLINE CELLULOSE Date/ Revised: 27/November/2012 Page 1 of 4 1. It . This Microcrystalline Cellulose . The wood pulp is depolymerized by acid hydrolysis and turned from a fibrous material to a white freely-flowing powder. MATERIAL SAFETY DATA SHEET. Have an order or account question? EMCOCEL XLM 90. Stabilizer composition of co-attrited microcrystalline cellulose and carboxymethylcellulose, method for making, and uses CN103842425B . (Microcrystalline Cellulose Market Pr. Product and Company Identification . In roller compaction, Avicel Microcrystalline cellulose improves compaction during the ribbon phase, enabling a trouble-free process while also preserving the plasticity of the compacts. IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING 1.1 Product identifiers Product name : Avicel PH-101 Product Number : 11365 Brand : Fluka CAS-No. }[eD-1-8$#Yi^$o8Nc6vwfw;wBT~[Rgi1?%T*/J:/'+Gf'Ae*j@{Rh+2oN|Sbtt;z#v8})F#z=:*]q+U>+ .e ^Q-{@ RPC t/(If>8P&%wNPMJw,VI2aUqRqe3bC,a;C&4RQSf*(=I$r{'%jmk1LUZV(*is6r&wQPAAoID4p?,"lp:wE+)v(_w 'yelVnMh=gIYjK:9v{$G;b8=lGG1_,h^0F2`a~Kusz1p#NS*qt6,F:7+Rma-4u} DINFzJ"Mlctg*~HEge