apoptosis impact factor 2022

Vucic D., Deshayes K., Ackerly H., Pisabarro M.T., Kadkhodayan S., Fairbrother W.J., Dixit V.M. Apoptosis : an international journal on programmed cell death Since constitutive NF-B activation and promoted inflammation have critical roles in tumor development, and have been observed in several cancer types, the regulation of said pathways has been suggested as a therapeutical approach. Finally, not only apoptosis but also necrosis is promoted as part of Smac mimetics treatment, unpacking new layers of IAPs relationship with tumoral development/progression. The site is secure. Proliferation and Apoptosis Pathways and Factors in Oral Squamous Cell Acta Crystallogr. FOIA Some researchers believe that apoptosis is an ally of . Livin, a novel inhibitor of apoptosis protein family member. Furthermore, xenograft models of MDA-MB-231 cell line had efficient induction of caspase-8 dependent apoptosis with a reduction in cIAP1 levels [113]. E3 ligase activity from IAPs RING domain allow the addition of Ub residues onto proteins involved in these signaling cascades. Internet Explorer). Oncogenesis seeks to encompass the breadth of the molecular biology of malignant change, and topics of particular interest include: The 2022journal citation metrics forOncogenesisare as follows: 2-year Impact Factor* (2021):6.524 The gene for neuronal apoptosis inhibitory protein is partially deleted in individuals with spinal muscular atrophy. Leaves. Le Tourneau C., Tao Y., Gomez-Roca C., Cristina V., Borcoman E., Deutsch E., Bahleda R., Calugaru V., Modesto A., Rouits E. Phase I Trial of Debio 1143, an Antagonist of Inhibitor of Apoptosis Proteins, Combined with Cisplatin Chemoradiotherapy in Patients with Locally Advanced Squamous Cell Carcinoma of the Head and Neck. Together, a constitutive ER stress that promotes upregulation of IAPs could, at least in part, explain the loss of apoptotic capability. Benetatos C.A., Mitsuuchi Y., Burns J.M., Neiman E.M., Condon S.M., Yu G., Seipel M.E., Kapoor G.S., LaPorte M.G., Rippin S.R. Many molecular mechanisms can be involved in resistance to chemotherapeutics, amongst which the evasion of apoptosis is frequently observed. Anti-Inflamm. A trend of increasing expression in more advanced diseases is also apparent. Flygare J.A., Beresini M., Budha N., Chan H., Chan I.T., Cheeti S., Cohen F., Deshayes K., Doerner K., Eckhardt S.G. [13], described the role of livin in cancer cell migration and invasion by means of the activation of Akt signaling and the induction of EMT in vitro and in vivo [13]. Abstract. However, the establishment of prevention programs, although still challenging, has allowed an increase in early detection and survival of patients [79]. Bianchini M., Levy E., Zucchini C., Pinski V., Macagno C., De Sanctis P., Valvassori L., Carinci P., Mordoh J. Despite the classical definition of CLL as a non-proliferative disease, some studies have paid attention to the proliferative nature of CLL cells found in pseudo-follicles formed in lymphoid organs [64]. Seeks to encompass the breadth of the molecular biology of malignant change. government site. This research received no external funding. In glioblastomas, livin is correlated with worse PFS and OS rates. In turn, given CLL cells fail to engage apoptotic programs in vivo although not in vitro, as observed by Collin et al. Apoptosis (Qualify) Latest Impact Factor IF 2021-2022| Trend, Prediction, Ranking & Analysis - Academic Accelerator Forum Toolbox Journal Matcher Manuscript Generator Research Trend Ranking Conference Ranking Country Ranking Institution Ranking Journal Ranking Scholar Ranking Database Conference Database Activated intrinsic apoptosis pathway is a key related prognostic parameter in acute myeloid leukemia. Table 1 summarizes the IAPs and cancer. Before In the last few decades, the discovery of hormonal alterations in breast cancer patients and the application of targeted therapies in populations with specific molecular characteristics have brought therapeutic promise. Interestingly, XIAP expression was comparable in normal and cancerous tissues in both young and older patients [70]. Chesi M., Mirza N.N., Garbitt V.M., Sharik M.E., Dueck A.C., Asmann Y.W., Akhmetzyanova I., Kosiorek H.E., Calcinotto A., Riggs D.L. Likewise, models of multiple myeloma and mammary tumors obtained very high percentages for durable care rates [145]. Accumulation of NIK activates IKK which, in turn, phosphorylates NF-B 2 (p100), transforming it into p52 and allowing nuclear translocation of the p52-RelB heterodimer [45,46]. Survivin and cyclin E2 genes expression in a cohort of Egyptian acute leukemia patients: Clinical importance and future prospects. Its overexpression was also associated with advanced cancer [80]. In particular, Adamkov et al. A Review of the Current Impact of Inhibitors of Apoptosis Proteins and However, previous studies had not found any correlation with said features [86]. Exploring mechanistic insight and molecular basis of cancer and related phenomena. Infante J.R., Dees E.C., Olszanski A.J., Dhuria S.V., Sen S., Cameron S., Cohen R.B. Nevertheless, while adaptive UPR has been shown to upregulate cIAP1, cIAP2, and XIAP through PERK (one of the sensors of the UPR), chronic ER stress was observed to downregulate XIAP protein levels, promoting a switch towards the apoptotic mechanism [134]. [72] observed higher cIAP-2 expression in stage II CRC with lymph node metastasis [72]. Correlation between XIAP expression and clinical features or prognosis in CRC have yielded conflicting results with some studies reporting no differential expression between cancerous and surrounding normal tissues, while others observed both higher protein and mRNA expression in the former [70,74]. Abbreviations: AML, acute myeloid leukemia; CLL, chronic lymphocytic leukemia; CRC, colorectal cancer; FU, fluorouracil; OS; overall survival. El-Mesallamy H.O., Hegab H.M., Kamal A.M. Ma O., Cai W.-W., Zender L., Dayaram T., Shen J., Herron A.J., Lowe S.W., Man T.-K., Lau C.C., Donehower L.A. MMP13, Birc2 (cIAP1), and Birc3 (cIAP2), amplified on chromosome 9, collaborate with p53 deficiency in mouse osteosarcoma progression. The authors were therefore prevented from giving a more concrete opinion about the role of TNF- in TNBC. Frontiers | Apoptosis in megakaryocytes: Safeguard and threat for Here, the development and effectiveness of the most clinically relevant Smac mimetics during pre-clinical experimentation will be described, as well as the results that preliminary investigation in the clinical contexts. Colorectal cancer (CRC), also known as bowel cancer, was the third most diagnosed cancer, and the second most fatal, worldwide in 2018, according to Las cifras del cancer report from the SEOM (Sociedad Espaola de Oncologa Mdica). The authors declare no conflict of interest. Staurosporine-induced cleavage of apoptosis-inducing factor in human Importantly, in these pathologies, including breast, colorectal and hematological cancers, the eight identified members are often overexpressed. However, and despite supporting evidence, in other cases, death promoted by administration of Smac mimetics is not dependent on TNF- or NF-kB. A phase I/II trial of Debio in combination with cisplatin in patients with locally advanced squamous cell carcinoma of the head and neck provided encouraging results including high OS, CR and PFS rates [140]. JCR Rank*:ONCOLOGY 61/245 Importantly, different authors failed to find similar results when studying younger AML patients. Inhibition of IAPs in experimental models with IAP overexpression achieved sensitization to apoptosis suggesting a potential therapeutic application [20,98,99,100,101]. In both studies, apollon was identified as a promising prognostic factor due to its association with a higher risk of relapse, worse response to chemotherapy and decreased survival. Also, a significant correlation between higher levels of XIAP and tumor differentiation, venous invasion and Dukes staging was found. Alternations in apoptosis of tumor cells and immune cells have become an important method for detailing the underlying mechanisms of hepatocellular carcinoma (HCC). Taken together, results from Tamm et al. Debio 1143/AT-406 was firstly described in 2011 shown to mimic AVPIs binding to BIR3. A small molecule Smac mimic potentiates TRAIL-and TNF-mediated cell death. the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in All in all, Birinapant showed moderate antitumoral activity, but efficacy was far from ideal. Med. Furthermore, the realization that Smac mimetics may have different roles on the immune system, apart from cIAPs involvement in NF-B activation, has catalyzed different uses of these agents. Dimeric Smac/DIABLO interacts with BIR2 and BIR3 IAP domains, ultimately leading to proteolytic cleavage and activation of procaspase-3 and procaspase-9, and the induction of caspase-3 enzymatic activity [97]. Karasawa H., Miura K., Fujibuchi W., Ishida K., Kaneko N., Kinouchi M., Okabe M., Ando T., Murata Y., Sasaki H. Down-regulation of cIAP2 enhances 5-FU sensitivity through the apoptotic pathway in human colon cancer cells. Both IAPs direct caspase inhibition and poly-Ub-dependent caspase degradation can be easily overcome after massive release of IBM-containing proteins from mitochondria, including Smac/DIABLO. Evolution of the number of published documents. These contribute to ubiquitin-protein ligase (E3) activity which promotes the addition of ubiquitin residues to lysines or methionines on proteins [28]. [57,58,59,60]. It would not be surprising to find that Smac mimetics resistance is not, at least in part, promoted by ER stress induction of IAPs overexpression, such that previously established doses of Smac mimetics might not be sufficient to overcome inhibition of apoptosis. [67] sensitized resistant CLL cells to cytotoxic agents by inhibiting survivin expression and inducing apoptosis in an ex vivo model of this microenvironment [67]. A later study, by Pluta et al. Promising results showed a possible correlation between clinical efficacy and TNF- positive TNBC patients with both LCL161 and paclitaxel. These results pointed out the potential benefits of using ICIs together with Smac mimetics as a way of increasing TNF-production, while forcing the TNFR pathway towards a caspase-8 dependent death. Also, U87MG orthotopic xenografts demonstrated delayed tumor growth upon administration of GDC-0152. The results of some of these approaches are collected in a review from Pakos-Zebrucka et. Accessibility P.C., J.P.-D., A.M. and F.A.-M. participated in the bibliographic search, discussion, and writing of the manuscript. Apoptosis is a tightly regulated process in which the balance between different pro- and anti-apoptotic proteins decides the cells fate. Through this web page, researchers can check the impact factor, total citation, journal quartile and journal aim & scope. It was, Higher expression of XIAP, cIAP1, cIAP2 and survivin was observed in, Modulation of XIAP expression sensitized CLL cells to chemotherapy in, Co-expression of survivin and cIAP1 was related with shorter OS and, Inhibition of survivin sensitized CLL cells to cytotoxic agents and induced. DeathBase provides a useful tool for anyone with an interest in apoptosis and cell death. However, in humans, defective expression of XIAP, due to deleterious mutations, is found to cause X-linked lymphoproliferative syndrome (XLP) type 2 [35,36]. Carter B.Z., Kornblau S.M., Tsao T., Wang R.Y., Schober W.D., Milella M., Sung H.G., Reed J.C., Andreeff M. Caspase-independent cell death in AML: Caspase inhibition in vitro with pan-caspase inhibitors or in vivo by XIAP or Survivin does not affect cell survival or prognosis. The new mutant strains escape the immunity and reduce the protective effect of the original vaccine , leading to drug resistance to the virus. Nuclear cIAP1 overexpression is a tumor stage-and grade-independent predictor of poor prognosis in human bladder cancer patients. The emergence of a series of SARS-CoV-2 variants has caused a huge impact on the vaccine-regulated immune barriers throughout the world. Yang Y., Fang S., Jensen J.P., Weissman A.M., Ashwell J.D. Cheung H., St Jean M., Beug S., Lejmi-Mrad R., LaCasse E., Baird S., Stojdl D., Screaton R., Korneluk R. SMG1 and NIK regulate apoptosis induced by Smac mimetic compounds. In addition, in some cancers, ER stress has been identified as responsible for the acquisition of resistance to chemotherapeutic agents. In these cases, BIR2 and BIR3 bind to IAP binding motif (IBM)-containing proteins, such as caspases, while BIR1 interacts with other signaling intermediates, such as TAB1 or TRAF1. Song J., Su H., Zhou Y.Y., Guo L.L. [121] are consistent with this role of TNF-. Smac mimetics are thus developed in an effort to decrease IAPs levels observed in cancers and other diseases in which their expression is dysregulated. Moreover, a trial assessing its efficacy on advanced ovarian, fallopian tube and peritoneal cancer had to be canceled early due to lack of clinical benefit ({"type":"clinical-trial","attrs":{"text":"NCT01681368","term_id":"NCT01681368"}}NCT01681368). Zhang et al. As a result, abnormal expression of inhibitor apoptosis proteins (IAPs) can lead to dysregulated apoptosis promoting the development of different pathologies. [62], it becomes apparent that the tumor microenvironment might have a role in these differences [62]. Guoan X., Xiaomin W., Hanning W., Kaiyun C., Hao L. Expression of X-linked inhibitor of apoptosis protein in human colorectal cancer and its correlation with prognosis. Along these lines, some studies have assessed the role of IAPs expression on survival and therapeutic response in children. Additionally, Smac mimetics killing efficacy was suggested to be dependent on other molecules, such as interferons (IFNs) or tumor necrosis factor- (TNF-) [18]. Childhood AML was recently defined as a significantly different disease from adult AML at the genetic level [54]. Dhuriya Y.K., Sharma D. Necroptosis: A regulated inflammatory mode of cell death. Youssef N.S., Hewedi I.H., Abd Raboh N.M. Immunohistochemical expression of survivin in breast carcinoma: Relationship with clinicopathological parameters, proliferation and molecular classification. For instance, NSCLC cell lines were sensitized to chemotherapy by the SM JP1201 even when TNF- expression was not high [125]. Apoptosis | Home - Springer As outlined above, cIAPs have important roles in the regulation of the signaling cascade following the binding of TNF- to its receptor. External citations are calculated by subtracting the number of self-citations from the total number of citations received by the journals documents. Li et al. Pluta P., Cebula-Obrzut B., Ehemann V., Pluta A., Wierzbowska A., Piekarski J., Bilski A., Nejc D., Kordek R., Robak T. Correlation of Smac/DIABLO protein expression with the clinico-pathological features of breast cancer patients. IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-B as well as cell survival and oncogenesis. No. Sl. Importantly, both processes are governed by the addition or deletion of Ub residues on complexes that lead to the activation of the kinases controlling NF-B activation [43]. The human IAP family is composed of eight members: NAIP, cIAP1, cIAP2, XIAP, Survivin, Bruce/Apollon, ML-IAP/Livin and ILP-2, although XIAP, cIAP1 and cIAP2 are the most extensively studied [7,8,9,10]. Yang Q.-H., Du C. Smac/DIABLO selectively reduces the levels of c-IAP1 and c-IAP2 but not that of XIAP and livin in HeLa cells. Pharmacol. and JavaScript. Therefore, it might be interesting to further investigate the pathways interacting to produce IAPs upregulation. Hussain A.R., Siraj A.K., Ahmed M., Bu R., Pratheeshkumar P., Alrashed A.M., Qadri Z., Ajarim D., Al-Dayel F., Beg S. XIAP over-expression is an independent poor prognostic marker in Middle Eastern breast cancer and can be targeted to induce efficient apoptosis. Krajewska M., Kim H., Kim C., Kang H., Welsh K., Matsuzawa S.-i., Tsukamoto M., Thomas R.G., Assa-Munt N., Piao Z. For safety reasons, due to the high toxicity of systemic delivery of TNF-, targeted delivery methods had to be developed. Phase I dose-escalation study of LCL161, an oral inhibitor of apoptosis proteins inhibitor, in patients with advanced solid tumors. Doron B., Abdelhamed S., Butler J.T., Hashmi S.K., Horton T.M., Kurre P. Transmissible ER stress reconfigures the AML bone marrow compartment. Globally, oral cancer is the most common head and neck malignancy with an estimated 34,864 new global cases in 2018 rising to 377,713 in 2020, more than doubling the 185,976 number cases observed in 1990 and demonstrating its rapidly increasing prevalence [1,2,3].Melanesia and Southcentral Asia exhibit the highest incidence of oral canceraccounting for approximately 52% of . IAPs and cancer. Evolution of the total number of citations and journal's self-citations received by a journal's published documents during the three previous years. In cancer, different factors, including hypoxia or genomic instability, increase the demand for protein production, resulting in accumulation of proteins, which end up promoting ER stress [130]. J.P.-D. and A.M. revised the manuscript. Correlated with metastasis, advanced stage and tumor size. Ashhab Y., Alian A., Polliack A., Panet A., Yehuda D.B. cIAP1 is most frequently expressed in nucleus while cIAP2 in the cytoplasm. Grzybowska-Izydorczyk O., Cebula B., Robak T., Smolewski P. Expression and prognostic significance of the inhibitor of apoptosis protein (IAP) family and its antagonists in chronic lymphocytic leukaemia. Chronic lymphocytic leukemia is the most common leukemia in adults. Although it is mostly a curable disease, when detected at early stages, when symptoms arise, cancer may already have advanced. The cytokine storm (CS) in hyperinflammation is characterized by high levels of cytokines, extreme activation of innate as well as adaptive immune cells and initiation of apoptosis. Although it is synthesized as a much longer precursor, in its mature form, it is composed of 184 amino acids. Evidence-Based Complementary and Alternative Medicine -. [82], reported differential subcellular expressions in breast cancer samples when cytoplasmic XIAP was observed in all the studied cases but nuclear staining in only 43% [82]. The P681R mutation in the spike protein, which is . The first human IAP was described in spinal muscular atrophy (SMA), when it was found to be partially deleted or mutated in type I SMA patients. Cancers showing no response to, or no expression of, TNF-, have been observed to be resistant to Smac mimetics treatment in some circumstances.
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