Curcumin, one such natural-based compound, has demonstrated several biological activities. Curcumin exhibits antioxidant activity, which can play a great role in the treatment of wounds.7,8Curcumin (a natural product), isolated from the rhizomes ofCurcuma longa, is used orally and topically in the treatment of wounds.Curcumin(o-methoxyphenolderivativecompound) possesses antioxidant activity and excites detoxi cation enzymes. Classification of Wounds and Phases of Wound Healing Process.
Overexpression of TRPM7 promotes the therapeutic effect of curcumin in One of the most investigated substances with pleiotropic effects in treating skin disorders is curcumin, the active ingredient of the medicinal plant Curcuma longa. Curcumin as Curecumin: From kitchen to clinic. Polshettiwar S.A., Sawant D.H., Abhale N.B., Chavan N.B., Baheti A.M., Wani M.S., Tagalpallewar A.A., Deshmukh C.D., Polshettiwar A.P. Interestingly, topical administration of zinc to surgical wounds significantly improves the healing process [58]. Curcumin, a natural extract from the rhizomes of Curcuma longa, is also known as a curcuminoid. These findings also provide a basis for identifying active hotspots of scientific interest, which can be used to direct future research projects. A trend analysis of publications each year is illustrated, displaying the pattern of articles published from 1942 to 2021. In order to increase the bioavailability and biofunctionality of the molecule, curcumin is combined with a variety of delivery systems, the most popular of which are nanoparticle, biopolymer, nanofiber, and hydrogel [31,32,33,34]. Shepherd A.A. Licensee MDPI, Basel, Switzerland. Dermal wound healing is subject to redox control.
Curcumin in Wound HealingA Bibliometric Analysis - Academia.edu Interestingly, its pleiotropic effect on several signaling pathwaysby modulating cellular regulatory systems, such as NF-B, AKT, growth factors, and Nrf2 transcription factor [92,93,94,95]might be explained by its well-established role in epigenetic mechanisms, such as DNA methylation and histone modification [96]. Finally, once closure of the wound has been achieved, apoptotic processes discard inflammatory cells from wound sites [88,89,90]. Effect of dietary turmeric (Curcuma longa) on iron-induced lipid peroxidation in the rat liver. Lal J. Turmeric, curcumin and our life: A review. The https:// ensures that you are connecting to the In vitro and in vivo studies have demonstrated the antioxidant activities of curcumin conferred by its electron-donating groups (i.e., the phenolic hydroxyl group) [76]. Salehi B., Rodrigues C.F., Peron G., DallAcqua S., Sharifi-Rad J., Azmi L., Shukla I., Singh Baghel U., Prakash Mishra A., Elissawy A.M., et al. To solve the question of whether curcumin is a suitable wound healing agent, we have summarized its biochemical and molecular effects during the different phases of wound healing, as well as evidence from epidemiological studies. Malnutrition is a common risk factor that might contribute to impaired wound healing [7,8,9]. official website and that any information you provide is encrypted Evans C. Malnutrition in the elderly: A multifactorial failure to thrive. The spice Curcuma longa is widely used throughout the world, including India. ABC of wound healing. 1Department of Zoology, Aligarh Muslim University, Aligarh 202002, India, 2Department of Computer Science and Engineering, Jamia Hamdard University, New Delhi 110062, India, 3College of Science and Arts, Najran University, Najran 11001, Saudi Arabia, 4School of Business, University of South-Eastern Norway, 3511 Hnefoss, Norway. The Cellular and Molecular Research Center of Iran University of Medical Sciences is the most collaborative, with 8 different collaborators followed by Biotechnology Research Center (5), Neurogenic Inflammation Research Center (5) and School of Pharmacy (5). With a total of 43,739 citations and 16,208 keywords, these articles were contributed by 5503 authors. Extracellular matrix proteins are crucial in this phase because they provide substrates for cell migration and structures that restore the function and integrity of the tissue [18]. Alven S., Nqoro X., Aderibigbe B.A. Curcumin, Aloe-vera and Ginger are popular natural medications (NMs) for treating wounds, however, the mechanisms by which these NMs apparently accelerate wound healing remain largely unknown. The aim of the present study is to present a bibliometric analysis of the recent literature concerning the wound-healing properties of curcumin. In terms of article counts, India came in front with the largest circle, followed by China, the United States, and so forth. Type 1 diabetes mellitus. Collaboration network of institutions. As a result, 320 keywords remained, arranged into 5 clusters with 23,481 links (Figure 5). demonstrated that in a full-thickness excisional wound-healing mouse model, poly lactic-co-glycolic acid (PLGA)-curcumin nanoparticles showed a twofold higher wound-healing activity compared with that of PLGA or dietary curcumin, suggesting the improved wound-healing efficacy of PLGA-curcumin nanoparticles than curcumin due to efficient drug delivery, improved solubility and bioavailability. Vitamin C seems to be involved in wound healing with several roles in cell migration and transformation, collagen synthesis, antioxidant response, and angiogenesis. ; methodology, A.M. and M.B. The blue cluster of keywords is connected with skin infection and includes the terms wound infection, wound healing, histopathology, chronic wound, wound and injuries, epithelization and skin injury. 1Department of Medical and Surgical Sciences and Advanced Technologies GF Ingrassia, University of Catania, Via S. Sofia 87, 95123 Catania, Italy; ti.tcinu@attihcrab.anitram (M.B. ; writingreview and editing: F.S.
Curcumin as a wound healing agent - ScienceDirect More recently, curcumin has been investigated extensively as an anti-cancer [12], anti-aging [13], and wound healing agent [11]. The overlay visualization analysis shows the evolution of keywords over time (Figure 6). The .gov means its official. The authors declare that no funds, grants, or other support were received during the preparation of this manuscript. It acts on various stages of the natural wound healing process to hasten healing. In recent years, several lines of evidence have pointed out biochemical and molecular effects of several nutrients in the wound healing process, supporting the notion that a complementary nutritional approach might be useful in wound treatment, especially for chronic non-healing wounds [10]. Gong C., Wu Q., Wang Y., Zhang D., Luo F., Zhao X., Qian Z. Based on our search and to the best of our knowledge, this is the first bibliometric review on the topic; hence, it is envisaged that it will encourage researchers to explore future research dimensions in the related field. Then the Cur/PCEC nanoparticles were incorporated with collagen and PVA to build a composite film used as a wound . Liposomal carrier, nanocapsule and micelles are some of the other drug delivery vehicles used with curcumin [32,33,34,35,36]. Peng X., Yan H., You Z., Wang P., Wang S. Clinical and protein metabolic efficacy of glutamine granules-supplemented enteral nutrition in severely burned patients. It is noted that the keywords chosen by the contributing authors are quite diverse, ranging from traditional keywords such as curcuma longa, turmeric and medicinal plant to keywords for modern integrated technologies to evaluate the effectiveness of curcumin bioavailability, such as nanoparticles, drug delivery, nano emulsion, tissue engineering and nanofibres. The most central and highly weighted keywords in this network are likely to represent research hotspots in this active field, with a further need for curcumin in wound-healing research pertaining to these topics and the associated research directions. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (, wound, wound healing, diet, nutrition, micronutrients, macronutrients, curcumin, amino-acids, vitamins, minerals. Wei Y., Yuan X., Wu G., Yang L. Climate change risk assessment: A bibliometric analysis based on web of science. Krausz A.E., Adler B.L., Cabral V., Navati M., Doerner J., Charafeddine R.A., Chandra D., Liang H., Gunther L., Clendaniel A., et al. Despite the large number of available reviews on this topic, a bibliometric tool-based meta-analysis is missing in the literature.
Microwave-Assisted Physically Cross-Linked Chitosan-Sodium - Springer As reviewed by Falanga [15], it is useful to divide the wound healing process into four overlapping steps of coagulation, inflammation, migration-proliferation, and remodeling (Figure 2). Yeung A.W.K., Horbaczuk M., Tzvetkov N.T., Mocan A., Carradori S., Maggi F., Marchewka J., Sut S., DallAcqua S., Gan R.-Y., et al.
Curcumin as a wound healing agent - ScienceDirect Meiyanto, Edy is placed first with 9 articles, followed by Sahebkar, Amirhossein and Jenie, Riris with 8 and 7 articles published, respectively, on curcumin as a wound-healing agent. In addition, curcumin appears to be beneficial for epithelialization [70] and for apoptotic processes that discard inflammatory cells from the wound site [88,89,90]. In 2013, the number of publications surpassed 50, which can be considered an inflection point. Several minerals are involved in the wound healing process due to their roles as enzyme structural factors, metalloenzymes, and antioxidants. Effect of vitamin A on reversing the inhibitory effect of cortisone on healing of open wounds in animals and man. To achieve the aim of the study, the data is analyzed using standard parameters such as the annual publication, contributing journals, countries, institutions and authors using SCOPUS analysis, VOSviewer and MS Excel software. Sustained wound healing activity of curcumin loaded oleic acid based polymeric bandage in a rat model. In line with its roles, recent evidence of vitamin D deficiency among venous and pressure ulcer patients has suggested the potential involvement of vitamin D in the wound healing process [53,54]. The Epigenetic Regulation of Wound Healing. To date, most of the current knowledge on wound healing derives from in vitro and in vivo studies, while epidemiological investigations are scarce. In acute woundscutaneous injuries that do not have an underpinning pathophysiological defectthe main evolutionary force may have been to achieve repair quickly and with the smallest amount of energy [2]. (a). Different visualization maps representing the collaboration network of authors, nations, and organizations were created where larger circles indicate more collaborations and stronger links between those who collaborate more frequently. Recently, in wounds of diabetic rats, it has been demonstrated that topical curcumin treatment enhances angiogenesis, thereby ameliorating the healing process [91]. The font size of the words on the bubble map represents how frequently the terms occur (multiple appearances in a single publication count as one). Wound-healing research has made significant strides, and it is an active and quickly growing field of scientific interest. The International Journal of Biological Macromolecules stands out as the most prolific publication source, having the most articles published (44) and also the most citations (2012), followed by the Journal of Ethnopharmacology (28 articles) and Current Pharmaceutical Design (20 articles), with 1231 and 812 citations, respectively. The rapid growth in publications from 1942 to 2021 is obvious from the diagram, and a trend analysis of the annually generated corpus from the top 3 contributing countriesIndia, China, and the United Statesis more interesting. Beyond macronutrients, several micronutrients play a crucial role in the wound healing process, as extensively reviewed [7,8,9,33]. Human skin wounds: A major and snowballing threat to public health and the economy. Additionally, bibliometric analysis of keyword co-occurrence is also addressed using VOSviewer software. However, only 4 and 22 institutions, respectively, participated in more than 20 and 10 articles. Meshram M.G., Kale B., Revankar R.P., Jadhav V.V. 8600 Rockville Pike Iyer V., Pumiglia K., DiPersio C.M.
Curcumin as a Wound Healing Agent | Request PDF - ResearchGate Li H.Y., Yang M., Li Z., Meng Z. Curcumin inhibits angiotensin II-induced inflammation and proliferation of rat vascular smooth muscle cells by elevating PPAR- activity and reducing oxidative stress. ; formal analysis: F.F., S.S.S. A total of 5503 authors contributed to the 1284 articles. Abe Y., Hashimoto S., Horie T. Curcumin inhibition of inflammatory cytokine production by human peripheral blood monocytes and alveolar macrophages. Among the curcuminoids, curcumin is the powerful substance which possesses anti-inflammatory, analgesic and wound healing properties 13, 14 . Since curcumin induces apoptosis of inflammatory cells during the early phase of wound healing, it could also accelerate the healing process by shortening the inflammatory phase. In old peoplewho are at the highest risk of chronic wounds also due to coexisting diseasesmalnutrition often consists of either protein-energy malnutrition or specific vitamin and mineral deficiencies [8]. Fats have structural functions in the lipid bilayer of cell membranes during tissue growth. With respect to wounds, Panchatcharam and colleagues have demonstrated that collagen fibers could mature earlier when wound rats are topically treated with curcumin [70]. As iron transports oxygen to the tissues, it is essential for tissue perfusion and collagen synthesis.
PDF Effectiveness of ozone-laser photodynamic combination therapy for Among minerals, zinc is essential for the inflammatory, proliferative, and remodeling phases by promoting immune response, collagen production, fibroblast proliferation, and epithelialization [8]. A total of 1284 journal articles, available in the SCOPUS database, were published from 1942 to 2019. In the proliferative and remodeling phases, it is essential for collagen production, fibroblast proliferation, and epithelialization by stimulating the activity of involved enzymes [8]. ; resources: D..M. Molecules. When annual productivity was compared, most countries/regions showed a positive surge in interest in the research field, for example, in India, USA, and China. In addition, vitamin A seems to work as a hormone that modulates the activity of epithelial and endothelial cells, melanocytes, and fibroblasts by binding to retinoic acid receptors [46]. In these studies curcumin has been shown to act at all stages of wound healing by enhancing granulation tissue formation, collagen deposition, tissue remodelling and wound contraction. India and Saudi Arabia (10) and India and South Korea (7) were the second-most frequent collaborators. Yuetian Y., Yujie L., Zhongheng Z., Zhichun G., Han Z., Qiongfang Z., Luyu Y., Cheng Z., Erzhen C. A bibliometric analysis using VOSviewer of publications on COVID-19. Hence, protein and energy requirements of chronic wound patients may rise by 250% and 50%, respectively [26]. Kirk S.J., Hurson M., Regan M.C., Holt D.R., Wasserkrug H.L., Barbul A. Arginine stimulates wound healing and immune function in elderly human beings. The most frequently used markers in bibliometric studiesarticle count, citation count and Hirsch index (H-index)were taken into consideration to measure the influence and impact of the scientific research conducted. It acts on various stages of the natural wound healing process to hasten healing. It has a long history of use in medicine, with the earliest known evidence dating back 6000 years [7]. and Bayat, M. are the closest partners with highest link strength of 15 among each other. The present study demonstrated the advancements in scientific knowledge on curcumin and wound healing between 1942 and 2021, based on the literature found in the SCOPUS database. Wu G., Bazer F.W., Davis T.A., Kim S.W., Li P., Marc Rhoads J., Carey Satterfield M., Smith S.B., Spencer T.E., Yin Y. Arginine metabolism and nutrition in growth, health and disease. Albina J.E., Gladden P., Walsh W.R. The top 10 journals in terms of the article count on the use of curcumin for wound healing were responsible for 14.48 percent of the corpus (Table 1) and 16.07 percent of the total citation count. Fereydouni N., Darroudi M., Movaffagh J., Shahroodi A., Butler A.E., Ganjali S., Sahebkar A. Curcumin nanofibers for the purpose of wound healing. The correct approach to wound management may effectively influence the clinical outcome.
Preparation of a novel curcumin nanoemulsion by ultrasonication and its Amini, A., Chien, S., Ghoreishi, S.K. HHS Vulnerability Disclosure, Help As far as China is concerned, research in the topic under consideration was initiated in 2009, after which China also witnessed an exponential growth withy=(0.62861.1311)x. The first is a precursor of nitric oxide and proline, which in turn are essential for the inflammatory process [34] and synthesis of collagen [35,36]. The green cluster consists of four research institutions, out of which three are from Mashhad University of Medical Sciences (Biotechnology Research Center, Neurogenic Inflammation Research Center and School of Pharmacy) and Halal Research Centre, Iran. It was found that curcumin is one of the trending molecules in terms of wound-healing applications. Since cells involved in wound healing require proteins for their formation and activity, protein loss may negatively affect the whole immune process. First, the PCEC polymer was used as a carrier to deliver curcumin by forming curcumin nanoparticles. Methicillin-resistant . In wound patients with adequate protein intake, the recommended dose of arginine supplementation is 4.5 g/day, while it is useless in the context of protein deficiency [39]. The formation of new blood vessels re-establishes tissue perfusion, allowing for the re-supply of oxygen and other nutrients [17]. Dai M., Zheng X., Xu X., Kong X., Li X., Guo G., Luo F., Zhao X., Wei Y.Q., Qian Z. Chitosan-alginate sponge: Preparation and application in curcumin delivery for dermal wound healing in rat. Harding K.G., Morris H.L., Patel G.K. Science, medicine and the future: Healing chronic wounds. In fact, curcumin was commonly used in traditional medicine for the treatment of biliary and hepatic disorders, cough, diabetic ulcers, rheumatism and sinusitis [11]. Particularly, curcumin could be involved in the process of endometriosis by decreasing the growth and number of endometriotic stromal cells [81]. The natural medications for wound healingCurcumin, Aloe-Vera and GingerDo not induce a significant effect on the migration kinematics of cultured fibroblasts. See Full PDF Download PDF. government site. Zhang Y., Cao H., Yu Z., Peng H.Y., Zhang C.J. Pulido-Moran M., Moreno-Fernandez J., Ramirez-Tortosa C., Ramirez-Tortosa M. Curcumin and Health. The anti-inflammatory effects of curcumin are also involved in other signaling pathways, such as peroxisome proliferator-activated receptor-gamma (PPAR-) and myeloid differentiation protein 2-TLR 4 co-receptor (TLR4-MD2) [65,66,67,68]. In 23 publications, China placed first among the USs collaborating partners, followed by India (22) and Iran (18). Treatment of a chronic hard-to-heal wound and its therapeutic impediments have always attracted great concern in health care and medical fields, bringing about substantial economically challenging burdens worldwide (1-5). Malnutrition. Agrawal D.K., Mishra P.K. On the subject of curcumins ability to treat wounds, 159 different journals published a total of 1284 articles from 98 different nations and 3658 different organizations.
How to conduct a bibliometric analysis: An overview and guidelines. H Wound healing . Particularly, in diabetic patients, higher glucose levels could interfere with the process of nutrient absorption, causing the depletion of several nutrients (i.e., magnesium, zinc, B12, B6, folic acid) [24]. Amini, A., Chien, S., Ghoreishi, S.K. In April 2022, we accessed the SCOPUS online database to identify publications with the search keyword turmeric OR curcum* AND wound. Nutrition in Wound Care Management: A Comprehensive Overview. Hussain Z., Thu H.E., Ng S.F., Khan S., Katas H. Nanoencapsulation, an efficient and promising approach to maximize wound healing efficacy of curcumin: A review of new trends and state-of-the-art. In contrast, evolutionary adaptations have probably not occurred in chronic wounds with pre-existing pathophysiological abnormalities, resulting in impaired healing [3]. Accessibility Therapeutic roles of curcumin: Lessons learned from clinical trials. Vitamin D deficiency in patients with chronic venous ulcers. In the proliferative stage, curcumin enhances fibroblast migration, granulation tissue formation, collagen deposition, and re-epithelialization. A tremendous rise in this area of research represents the increasing interest in wound-healing applications of curcumin. Curcumin prevents maleate-induced nephrotoxicity: Relation to hemodynamic alterations, oxidative stress, mitochondrial oxygen consumption and activity of respiratory complex I. Zheng Q.T., Yang Z.H., Yu L.Y., Ren Y.Y., Huang Q.X., Liu Q., Ma X.Y., Chen Z.K., Wang Z.B., Zheng X. Synthesis and antioxidant activity of curcumin analogs. Hence, further efforts are needed to improve our scientific understanding of the repair process and how that knowledge can be used to develop new approaches to treatment. Additionally, it dramatically lowers the expression of antioxidant enzymes, one of the primary causes of inflammation and the oxidation process [15]. The claims have to abide by the FDAs regulatory requirements [28,29,30]. Huang M.T., Lysz T., Ferraro T., Abidi T.F., Laskin J.D., Conney A.H. Inhibitory effects of curcumin on in vitro lipoxygenase and cyclooxygenase activities in mouse epidermis. Curcumin has been used to treat wounds since ancient times, but only recently have a number of studies provided scientific evidence of its effectiveness in treating both acute and chronic wounds [12]. The top 10 trending keywords identified from the overlay visualization of keywords include curcumol, hydrogels, nanocomposites, wound healing assay, nanomaterial, nano pharmaceutics, biocompatibility, nanofiber, chitosan and biomaterial. Integrin alpha3beta1 directs the stabilization of a polarized lamellipodium in epithelial cells through activation of Rac1. Although curcumin could be considered as a wound healing agent, especially if topically administered, further research in wound patients is recommended to achieve appropriate nutritional approaches for wound management. Phases and specific events of the wound healing process. In case patients lose more than 10% lean body mass, wound healing competes with body demands to restore lean mass: The metabolism gives priority to healing in patients who lose up to 20%, while it delays healing to restore lean body mass in those who lose more than 30% [25,28]. More recently, it has been demonstrated that curcumin might modulate physiological and molecular events involved in the inflammatory and proliferative phases of the wound healing process [60]. During inflammation, the up-regulation of inflammatory mediators (i.e., cytokines and chemokines) activates NF-B, which in turn translocates to the nucleus [63]. Top 10 authors from an article count perspective. Arginine and glutamine exhibit several metabolic, enzymatic, antioxidant, and anti-inflammatory properties that are involved in the inflammatory phase [34,37,38,40,42] and in collagen synthesis [35,36]. Ravindranath V., Chandrasekhara N. Absorption and tissue distribution of curcumin in rats. Curcumin and its analogues: Potential anticancer agents. The size of the circle is directly related to the documents that each country generated, and the fine lines demonstrate the collaboration strength. Curcumin in Wound HealingA Bibliometric Analysis. ), 2General and Emergency Surgery Department, Garibaldi Hospital, Piazza Santa Maria di Ges, 95100 Catania, Italy; ti.liamtoh@alove_eppesuig, 3Department of General Surgery and Medical-Surgical Specialties, University of Catania, Via Plebiscito 628, 95124 Catania, Italy; ti.tcinu@elisabg. Impediments to wound healing. Received 2019 Jan 25; Accepted 2019 Mar 1. Keywords relevant to the wound-healing applications of curcumin and having occurrences greater than 10 were retained, and the rest were removed. These keywords not only demonstrate the current research directions but also suggest that a variety of techniques are being employed to use curcumin in healing acute as well as chronic wounds. The co-occurrence of total keywords, authors keywords and co-authorship analysis was performed by using the full counting method showing only the elements connected with each other. The International Journal of Biological Macromolecules also has the most cited article, with 489 citations. Interestingly, vitamin A supplementation counteracts the delay in wound healing caused by corticosteroids for the treatment of inflammatory diseases [47] by down-regulating TGF- and insulin-like growth factor-1 (IGF-1) [48]. ; Ramakrishna, Seeram; Sahebkar, Amirhossein; Maheshwari, R.K. and Hussain, Zahid. It has also been observed that genetic engineering and biotechnology have recently been employed to address the commercial implications of curcumin. Jagetia G.C., Rajanikant G.K. Role of arginine in superficial wound healing in man. In 1910, Milobedzka and colleagues described for the first time the structure of curcumin (Figure 3), one of the three curcuminoids extracted from the powdered rhizome of turmeric plant (Curcuma longa) [59].
Polymer-Based Materials Loaded with Curcumin for Wound Healing To meet the increased need of energy, especially during the proliferative phase, wounds also metabolize carbohydrates and fats [26], which in turn are necessary for fibroblast and leukocyte activities, secretion of hormones and growth factors, and structural functions [29,30]. ; methodology: S.S.S. To name, firstly hemostasis driven by vasoconstriction and complementing cascades, secondly, inflammation driven by vasodilation and activation of macrophage. When we decided whether an article should be included, we first considered its relevance to curcumin as a wound-healing agent. A previous study has also demonstrated that curcumin reduces the epithelialization period of treated wounds if compared with the control group [70]. It also increases fibroblast migration, granulation tissue development, collagen deposition, and overall re-epithelization to improve proliferation. When comparing annual output, the majority of journals including the International Journal of Biological Macromolecules, Current Pharmaceutical Design, and the International Journal of Molecular Sciences demonstrated a growth in this particular field of research. Due to the relatively low level of collaboration across these institutes, initiatives to build deeper links may help this field advance in the future. Plausible explanations are that growth factors might be trapped by the extracellular matrix [20] or that they might be excessively degraded by proteases [21]. After 2018, the annual publishing doubled with an average of 117 articles per year, reaching its peak in 2021 (254 articles/year). For the purpose, curcumin-loaded chitosan and sodium alginate membranes were developed using microwave at fixed frequency of 2450 MHz, power 350 W for 60 s, and tested for their . In line with the Special Issue Curcumin in Health and Disease, we have focused on the beneficial effects of curcumin, which exerts its anti-inflammatory and antioxidant properties during the different phases of the wound healing process [11]. The importance of curcumin in every stage of wound healing has been established by recent investigations. However, to what extent they support wound healing process remains unclear until now.
Curcumin nanoparticles incorporated in PVA/collagen composite films
Anew Blackhead Remover,
Los Angeles County Pool Technician Certification,
Outdoor Rectangle Dining Table With Umbrella Hole,
Articles C